476 Severe Autoimmunity with Polyarticular Joint Disease Requiring Anti-TNF Therapy and T+B-NK+ Immunodeficiency in a Family with Small Stature and Intermediate Radiation Sensitivity

IgE, and atopy. Results: We measured the total serum IgE of 155 children. The number of obese and normal weight children with family history of atopic disease who had high level of total serum IgE were 30 and 25 respectively, whereas these children who had normal level of total serum IgE were 6 and 15 respectively [OR 1⁄4 1.9 (95% CI 0.9-3.9)]. On the other hand, obese and normal weight children without family history of atopic disease who had high level of total serum IgE were 21 and 11 respectively, whereas these children who had normal level of total serum IgE were 18 and 29 respectively [OR 1⁄4 1.7 (95% CI 1.1-2.7)]. The number of obese and normal weight children without family history of atopic disease who had atopy were 38 and 9 respectively, whereas these children who had non-atopy were 2 and 31 respectively [OR 1⁄4 13.3 (95% CI 3.5-52)], but there was no relationship between atopy and obesity in group with family history of atopic disease (P 1⁄4 0.314). Conclusions: There were relationship between high level of total serum IgE and obesity in group with and without family history of atopic disease and also relationship between atopy and obesity in group without family history of atopic disease.